USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: P35998 USC-OGP 2-DE database:  P35998 P35998 General information about the entry View entry in simple text format Entry name PRS7_HUMAN Primary accession number P35998 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=26S protease regulatory subunit 7; AltName: Full=26S proteasome AAA-ATPase subunit RPT1; AltName: Full=Proteasome 26S subunit ATPase 2; AltName: Full=Protein MSS1;. Gene name Name=PSMC2 Synonyms=MSS1 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-5 {PLATELET 4-5} Homo sapiens (Human)   map experimental info   PLATELET_4-5 MAP LOCATIONS: SPOT OGP-0191: pI=4.69; Mw=25452 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1169: pI=5.83; Mw=47236 Cross-references UniProtKB/Swiss-Prot P35998; PRS7_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name PRS7_HUMAN Primary accession number P35998 Secondary accession number(s) A4D0Q1 B7Z5E2 Q3LIA5 Q9UDI3 Sequence was last modified on  January 23, 2007 (version 3) Annotations were last modified on  March 15, 2017 (version 176) Name and origin of the protein Description RecName: Full=26S protease regulatory subunit 7; AltName: Full=26S proteasome AAA-ATPase subunit RPT1; AltName: Full=Proteasome 26S subunit ATPase 2; AltName: Full=Protein MSS1; Gene name Name=PSMC2 Synonyms=MSS1 Encoded on Name=PSMC2; Synonyms=MSS1 Keywords 3D-structure; Acetylation; Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Host-virus interaction; Nucleotide-binding; Nucleus; Proteasome; Reference proteome. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL D11094; BAA01868.1; -; mRNA EMBL AB075520; BAE45763.1; -; mRNA EMBL AK298821; BAH12878.1; -; mRNA EMBL AC004668; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL AC093701; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH236947; EAL24412.1; -; Genomic_DNA EMBL CH471070; EAW83332.1; -; Genomic_DNA EMBL BC002589; AAH02589.1; -; mRNA CCDS CCDS5731.1; -. [P35998-1]; . PIR S24353; S24353; . RefSeq NP_001191382.1; NM_001204453.1; . RefSeq NP_002794.1; NM_002803.3. [P35998-1]; . UniGene Hs.437366; -; . PDB 5GJQ; EM; 4.50 A; H=1-433 PDB 5GJR; EM; 3.50 A; H/v=1-433 PDB 5L4G; EM; 4.02 A; H=1-433 PDB 5T0C; EM; 3.80 A; AA/BA=1-433 PDB 5T0G; EM; 4.40 A; A=1-433 PDB 5T0H; EM; 6.80 A; A=1-433 PDB 5T0I; EM; 8.00 A; A=1-433 PDB 5T0J; EM; 8.00 A; A=1-433 PDBsum 5GJQ; -; . PDBsum 5GJR; -; . PDBsum 5L4G; -; . PDBsum 5T0C; -; . PDBsum 5T0G; -; . PDBsum 5T0H; -; . PDBsum 5T0I; -; . PDBsum 5T0J; -; . ProteinModelPortal P35998; -; . SMR P35998; -; . BioGrid 111674; 158; . DIP DIP-27554N; -; . IntAct P35998; 56; . MINT MINT-1163662; -; . STRING 9606.ENSP00000292644; -; . iPTMnet P35998; -; . PhosphoSitePlus P35998; -; . SwissPalm P35998; -; . BioMuta PSMC2; -; . DMDM 547930; -; . OGP P35998; -; . REPRODUCTION-2DPAGE IPI00021435; -; . REPRODUCTION-2DPAGE P35998; -; . EPD P35998; -; . MaxQB P35998; -; . PaxDb P35998; -; . PeptideAtlas P35998; -; . PRIDE P35998; -; . DNASU 5701; -; . Ensembl ENST00000292644; ENSP00000292644; ENSG00000161057. [P35998-1]; . Ensembl ENST00000435765; ENSP00000391211; ENSG00000161057. [P35998-1]; . GeneID 5701; -; . KEGG hsa:5701; -; . UCSC uc003vbs.4; human. [P35998-1]; . CTD 5701; -; . DisGeNET 5701; -; . GeneCards PSMC2; -; . HGNC HGNC:9548; PSMC2; . HPA HPA019238; -; . HPA HPA049621; -; . MIM 154365; gene; . neXtProt NX_P35998; -; . OpenTargets ENSG00000161057; -; . PharmGKB PA33893; -; . eggNOG KOG0729; Eukaryota; . eggNOG COG1222; LUCA; . GeneTree ENSGT00550000074978; -; . HOGENOM HOG000225143; -; . HOVERGEN HBG000109; -; . InParanoid P35998; -; . KO K03061; -; . OMA FQVARCT; -; . OrthoDB EOG091G096W; -; . PhylomeDB P35998; -; . TreeFam TF105661; -; . Reactome R-HSA-1169091; Activation of NF-kappaB in B cells; . Reactome R-HSA-1234176; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; . Reactome R-HSA-1236974; ER-Phagosome pathway; . Reactome R-HSA-1236978; Cross-presentation of soluble exogenous antigens (endosomes); . Reactome R-HSA-174084; Autodegradation of Cdh1 by Cdh1:APC/C; . Reactome R-HSA-174113; SCF-beta-TrCP mediated degradation of Emi1; . Reactome R-HSA-174154; APC/C:Cdc20 mediated degradation of Securin; . Reactome R-HSA-174178; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; . Reactome R-HSA-174184; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; . Reactome R-HSA-180534; Vpu mediated degradation of CD4; . Reactome R-HSA-180585; Vif-mediated degradation of APOBEC3G; . Reactome R-HSA-187577; SCF(Skp2)-mediated degradation of p27/p21; . Reactome R-HSA-195253; Degradation of beta-catenin by the destruction complex; . Reactome R-HSA-202424; Downstream TCR signaling; . Reactome R-HSA-211733; Regulation of activated PAK-2p34 by proteasome mediated degradation; . Reactome R-HSA-2467813; Separation of Sister Chromatids; . Reactome R-HSA-2871837; FCERI mediated NF-kB activation; . Reactome R-HSA-349425; Autodegradation of the E3 ubiquitin ligase COP1; . Reactome R-HSA-350562; Regulation of ornithine decarboxylase (ODC); . Reactome R-HSA-382556; ABC-family proteins mediated transport; . Reactome R-HSA-450408; AUF1 (hnRNP D0) binds and destabilizes mRNA; . Reactome R-HSA-4608870; Asymmetric localization of PCP proteins; . Reactome R-HSA-4641257; Degradation of AXIN; . Reactome R-HSA-4641258; Degradation of DVL; . Reactome R-HSA-5358346; Hedgehog ligand biogenesis; . Reactome R-HSA-5362768; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; . Reactome R-HSA-5607761; Dectin-1 mediated noncanonical NF-kB signaling; . Reactome R-HSA-5607764; CLEC7A (Dectin-1) signaling; . Reactome R-HSA-5610780; Degradation of GLI1 by the proteasome; . Reactome R-HSA-5610783; Degradation of GLI2 by the proteasome; . Reactome R-HSA-5610785; GLI3 is processed to GLI3R by the proteasome; . Reactome R-HSA-5632684; Hedgehog 'on' state; . Reactome R-HSA-5658442; Regulation of RAS by GAPs; . Reactome R-HSA-5668541; TNFR2 non-canonical NF-kB pathway; . Reactome R-HSA-5676590; NIK-->noncanonical NF-kB signaling; . Reactome R-HSA-5678895; Defective CFTR causes cystic fibrosis; . Reactome R-HSA-5687128; MAPK6/MAPK4 signaling; . Reactome R-HSA-5689603; UCH proteinases; . Reactome R-HSA-5689880; Ub-specific processing proteases; . Reactome R-HSA-6798695; Neutrophil degranulation; . Reactome R-HSA-68827; CDT1 association with the CDC6:ORC:origin complex; . Reactome R-HSA-68949; Orc1 removal from chromatin; . Reactome R-HSA-69017; CDK-mediated phosphorylation and removal of Cdc6; . Reactome R-HSA-69229; Ubiquitin-dependent degradation of Cyclin D1; . Reactome R-HSA-69481; G2/M Checkpoints; . Reactome R-HSA-69601; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; . Reactome R-HSA-8852276; The role of GTSE1 in G2/M progression after G2 checkpoint; . Reactome R-HSA-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; . Reactome R-HSA-983168; Antigen processing: Ubiquitination & Proteasome degradation; . ChiTaRS PSMC2; human; . GeneWiki PSMC2; -; . GenomeRNAi 5701; -; . PRO PR:P35998; -; . Proteomes UP000005640; Chromosome 7; . Bgee ENSG00000161057; -; . CleanEx HS_PSMC2; -; . ExpressionAtlas P35998; baseline and differential; . Genevisible P35998; HS; . GO GO:0005737; C:cytoplasm; TAS:UniProtKB; . GO GO:0005829; C:cytosol; IDA:HPA; . GO GO:0031597; C:cytosolic proteasome complex; IBA:GO_Central; . GO GO:0005576; C:extracellular region; TAS:Reactome; . GO GO:1904813; C:ficolin-1-rich granule lumen; TAS:Reactome; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0031595; C:nuclear proteasome complex; IBA:GO_Central; . GO GO:0005654; C:nucleoplasm; TAS:Reactome; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0000932; C:P-body; ISS:UniProtKB; . GO GO:0022624; C:proteasome accessory complex; ISS:UniProtKB; . GO GO:0000502; C:proteasome complex; IDA:UniProtKB; . GO GO:0008540; C:proteasome regulatory particle; base subcomplex; IBA:GO_Central GO GO:0034774; C:secretory granule lumen; TAS:Reactome; . GO GO:0005524; F:ATP binding; IEA:UniProtKB-KW; . GO GO:0016887; F:ATPase activity; IDA:UniProtKB; . GO GO:0036402; F:proteasome-activating ATPase activity; IBA:GO_Central; . GO GO:0017025; F:TBP-class protein binding; IBA:GO_Central; . GO GO:0031145; P:anaphase-promoting complex-dependent catabolic process; TAS:Reactome; . GO GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I; TAP-dependent; TAS:Reactome GO GO:0030433; P:ER-associated ubiquitin-dependent protein catabolic process; IBA:GO_Central; . GO GO:0038095; P:Fc-epsilon receptor signaling pathway; TAS:Reactome; . GO GO:0000165; P:MAPK cascade; TAS:Reactome; . GO GO:0090090; P:negative regulation of canonical Wnt signaling pathway; TAS:Reactome; . GO GO:0010972; P:negative regulation of G2/M transition of mitotic cell cycle; TAS:Reactome; . GO GO:0051436; P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome; . GO GO:0043312; P:neutrophil degranulation; TAS:Reactome; . GO GO:0038061; P:NIK/NF-kappaB signaling; TAS:Reactome; . GO GO:0001649; P:osteoblast differentiation; IDA:UniProtKB; . GO GO:0090263; P:positive regulation of canonical Wnt signaling pathway; TAS:Reactome; . GO GO:0045899; P:positive regulation of RNA polymerase II transcriptional preinitiation complex assembly; IBA:GO_Central; . GO GO:0051437; P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition; TAS:Reactome; . GO GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; TAS:Reactome; . GO GO:0016579; P:protein deubiquitination; TAS:Reactome; . GO GO:0000209; P:protein polyubiquitination; TAS:Reactome; . GO GO:0006521; P:regulation of cellular amino acid metabolic process; TAS:Reactome; . GO GO:0043488; P:regulation of mRNA stability; TAS:Reactome; . GO GO:0061418; P:regulation of transcription from RNA polymerase II promoter in response to hypoxia; TAS:Reactome; . GO GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; TAS:Reactome; . GO GO:0002223; P:stimulatory C-type lectin receptor signaling pathway; TAS:Reactome; . GO GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome; . GO GO:0055085; P:transmembrane transport; TAS:Reactome; . GO GO:0033209; P:tumor necrosis factor-mediated signaling pathway; TAS:Reactome; . GO GO:0006511; P:ubiquitin-dependent protein catabolic process; IDA:UniProtKB; . GO GO:0016032; P:viral process; IEA:UniProtKB-KW; . GO GO:0060071; P:Wnt signaling pathway; planar cell polarity pathway; TAS:Reactome Gene3D 3.40.50.300; -; 1; . InterPro IPR005937; 26S_Psome_P45; . InterPro IPR003593; AAA+_ATPase; . InterPro IPR003959; ATPase_AAA_core; . InterPro IPR003960; ATPase_AAA_CS; . InterPro IPR027417; P-loop_NTPase; . Pfam PF00004; AAA; 1; . SMART SM00382; AAA; 1; . SUPFAM SSF52540; SSF52540; 1; . TIGRFAMs TIGR01242; 26Sp45; 1; . PROSITE PS00674; AAA; 1; .

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